１．原著論文 (*Corresponding Author)
 

(1) Anzai K, Tsuruya K, Ida K, Kagawa T, Inagaki Y, Kamiya A*. Kruppel-like factor 15 induces the development of mature hepatocyte-like cells from hepatoblasts. Sci Rep. 2021 Sep 17;11(1):18551. doi: 10.1038/s41598-021-97937-6.

・マウス胎仔肝前駆細胞およびヒト多能性幹細胞由来肝前駆細胞の成熟化を誘導する新規因子を同定した。

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(2) AlOgayil N, Bauermeister K, Galvez JH, Venkatesh VS, Zhuang QK, Chang ML, Davey RA, Zajac JD, Ida K, Kamiya A, Taketo T, Bourque G, Naumova AK. Distinct roles of androgen receptor, estrogen receptor alpha, and BCL6 in the establishment of sex-biased DNA methylation in mouse liver. Sci Rep. 2021 11(1):13766. doi: 10.1038/s41598-021-93216-6.

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(3) Tsuneishi R, Saku N, Miyata S, Akiyama S, Javaregowda PK, Ite K, Takashima N, Toyoda M, Kimura T, Kuroda M, Nakazawa A, Kasahara M, Nonaka H, Kamiya A, Kiyono T, Yamauchi J, Umezawa A. Ammonia-based enrichment and long-term propagation of zone I hepatocyte-like cells.

Sci Rep. 2021 11(1):11381. doi: 10.1038/s41598-021-90708-3. PMID: 34059723

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(4) Hamada T, Nakamura A, Soyama A, Sakai Y, Miyoshi T, Yamaguchi S, Hidaka M, Hara T, Kugiyama T, Takatsuki M, Kamiya A, Nakayama K, Eguchi S. Bile duct reconstruction using scaffold-free tubular constructs created by Bio-3D printer. Regen Ther. 2021 16:81-89. doi: 10.1016/j.reth.2021.02.001.

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(5) Kasahara D, Sumiyoshi H, Endo H, Yanagawa T, Nakano Y, Matsuki Y, Nakao S, Kamiya A, Kimura H, Inagaki Y. Visualization and isolation of zone-specific murine hepatocytes that maintain distinct cytochrome P450 oxidase expression in primary culture. Biochem Biophys Res Commun. 528, 420-425. 2020. doi: 10.1016/j.bbrc.2020.05.202.

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(6）Chikada H, Ida K, Nishikawa Y, Inagaki Y, Kamiya A*. Liver-specific knockout of B cell lymphoma 6 suppresses progression of non-alcoholic steatohepatitis in mice. Sci Rep. 10, 9704. 2020, doi: 10.1038/s41598-020-66539-z.

・肝臓におけるBcl6の発現が、非アルコール性脂肪肝炎（NASH）の発症に重要なことを示した。

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(7) Nakano Y, Kamiya A, Sumiyoshi H, Tsuruya K, Kagawa T, Inagaki Y. A novel deactivation factor of fibrogenic hepatic stellate cells induces regression of liver fibrosis in mice. Hepatology. 71, 1437-1452, 2020. doi: 10.1002/hep.30965.

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(8) Sato A, Kakinuma S, Miyoshi M, Kamiya A, Tsunoda T, Kaneko S, Tsuchiya J, Shimizu T, Takeichi E, Nitta S, Kawai-Kitahata F, Murakawa M, Itsui Y, Nakagawa M, Azuma S, Koshikawa N, Seiki M, Nakauchi H, Asahina Y, Watanabe M. Vasoactive Intestinal Peptide Derived from Liver Mesenchymal Cells Mediates Tight Junction Assembly in Mouse Intrahepatic Bile Ducts. Hepatology Communications, 4, 235-254, 2019. doi: 10.1002/hep4.1459.

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(9) Tsunoda T, Kakinuma S, Miyoshi M, Kamiya A, Kaneko S, Sato A, Tsuchiya J, Nitta S, Kawai-Kitahata F, Murakawa M, Itsui Y, Nakagawa M, Azuma S, Sogo T, Komatsu H, Mukouchi R, Inui A, Fujisawa T, Nakauchi H, Asahina Y, Watanabe M. Loss of Fibrocystin Promotes Interleukin-8-Dependent Proliferation and CTGF Production of Biliary Epithelium. J Hepatol. 71, 143-152, 2019. doi: 10.1016/j.jhep.2019.02.024.

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(10) Miyoshi M, Kakinuma S, Kamiya A, Tsunoda T, Tsuchiya J, Sato A, Kaneko S, Nitta S, Kawai-Kitahata F, Murakawa M, Itsui Y, Nakagawa M, Azuma S, Nakauchi H, Asahina Y, Watanabe M. LIM homeobox 2 promotes interaction between human iPS-derived hepatic progenitors and iPS-derived hepatic stellate-like cells. Sci Rep. 9, 2072, 2019.

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(11) Yanagawa T, Sumiyoshi H, Higashi K, Nakao S, Higashiyama R, Fukumitsu H, Minakawa K, Chiba Y, Suzuki Y, Sumida K, Saito K, Kamiya A, Inagaki Y.　Identification of a Novel Bone Marrow Cell-Derived Accelerator of Fibrotic Liver Regeneration through Mobilization of Hepatic Progenitor Cells in Mice.　Stem Cells.  37, 89-101, 2019. doi: 10.1002/stem.2916.

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(12) Kamiya A*, Chikada H, Ida K, Ando E, Tsuruya K, Kagawa T, Inagaki Y. An in vitro model of polycystic liver disease using genome-edited human inducible pluripotent stem cells. Stem Cell Res. 32, 17-24, 2018.

・ヒトiPS細胞をゲノム編集酵素によって改変し、ヒト多発肝のう胞症の試験管内再現系を構築した。

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(13) Schwarz BA, Cetinbas M, Clement K, Walsh RM, Cheloufi S, Gu H, Langkabel J, Kamiya A, Schorle H, Meissner A, Sadreyev RI, Hochedlinger K. Prospective Isolation of Poised iPSC Intermediates Reveals Principles of Cellular Reprogramming. Cell Stem Cell. 23, 289-305, 2018.

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(14) Chikada H, Ida K, Ando E, Inagaki Y, Sakamoto A, Kamiya A*. Establishment and analysis of a mouse model that regulates sex-related differences in liver drug metabolism. Lab Invest. 2018 doi: 10.1038/s41374-018-0088-6

・肝臓におけるBcl6が、薬物代謝酵素であるCYPファミリーの発現の雌雄差を決定する重要な転写因子であることを証明した。

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(15) Nakano Y, Nakao S, Sumiyoshi H, Mikami K, Tanno Y, Sueoka M, Kasahara D, Kimura H, Moro T, Kamiya A, Hozumi K, Inagaki Y. Identification of a novel alpha-fetoprotein-expressing cell population induced by the Jagged1/Notch2 signal in murine fibrotic liver. Hepatol Commun. 1, 215-229. 2017. doi: 10.1002/hep4.1026

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(16) Kaneko S, Kakinuma S, Asahina Y, Kamiya A, Miyoshi M, Tsunoda T, Nitta S, Asano Y, Nagata H, Otani S, Kawai-Kitahata F, Murakawa M, Itsui Y, Nakagawa M, Azuma S, Nakauchi H, Nishitsuji H, Ujino S, Shimotohno K, Iwamoto M, Watashi K, Wakita T, Watanabe M. Human induced pluripotent stem cell-derived hepatic cell lines as a new model for host interaction with hepatitis B virus. Sci Rep. 6, 29358, 2016

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(17) Anzai K, Chikada H, Tsuruya K, Ida K, Kagawa T, Inagaki Y, Mine T, Kamiya A*. Foetal hepatic progenitor cells assume a cholangiocytic cell phenotype during two-dimensional pre-culture. Sci Rep. 6, 28283, 2016.

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(18) Otani S, Kakinuma S, Kamiya A, Goto F, Kaneko S, Miyoshi M, Tsunoda T, Asano Y, Kawai-Kitahata F, Nitta S, Nakata T, Okamoto R, Itsui Y, Nakagawa M, Azuma S, Asahina Y, Yamaguchi T, Koshikawa N, Seiki M, Nakauchi H, Watanabe M. Matrix Metalloproteinase-14 Mediates Formation of Bile Ducts and Hepatic Maturation of Fetal Hepatic Progenitor Cells. Biochem Biophys Res Commun. 469, 1062-8, 2016.

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(19) Yanagida A, Mizuno N, Yamazaki Y, Kato-Itoh M, Umino A, Sato H, Ito K, Yamaguchi T, Nakauchi H, Kamiya A*. Investigation of bi-potent differentiation of hepatoblasts using inducible diphtheria toxin receptor-transgenic mice.　Hepatol Res. 46, 816-28, 2016

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(20) Chikada H, Ito K, Yanagida A, Nakauchi H, and Kamiya A*. The basic helix-loop-helix transcription factor, Mist1, induces maturation of mouse fetal hepatoblasts.　Sci. Rep. 2015 Sep.

・肝前駆細胞の成熟化を促進する新規因子としてのMist1を報告した論文。薬物代謝の中心的酵素であるCYP3A11等の発現や活性化をMist1が制御する。

 

(21) Kamiya A*, Ito K, Yanagida A, Chikada H, Iwama A, Nakauchi H. MEK-ERK activity regulates the proliferative activity of fetal hepatoblasts through accumulation of p16/19cdkn2a.　Stem Cells Dev. 2015 Jul 16.

・肝前駆細胞のin vitro増幅に関するシグナル経路の解析。MEK-ERK Pathwayの過剰な活性化によって、肝前駆細胞のp16/19cdkインヒビターの発現活性化・細胞増殖停止が引き起こされる。

 

(22) Yanagida A, Chikada H, Ito K, Umino A, Kato-Itoh M, Yamazaki Y, Sato H, Kobayashi T, Yamaguchi T, Nakayama KI, Nakauchi H, Kamiya A*. Liver maturation deficiency in p57Kip2-/- mice occurs in a hepatocytic p57Kip2 expression-independent manner.　Dev Biol. 2015 Jul 9. pii: S0012-1606(15)30037-3.　

・胎児期における肝発生と細胞周期関連因子との関係について解析した論文。発生過程における非実質細胞にp57Kip2が強く発現しており、この発現が肝発生に重要なことを示唆した論文。

 

(23) Tsuruya K, Chikada H, Ida K, Anzai K, Kagawa Y, Inagaki Y, Mine T, and Kamiya A*, A paracrine mechanism accelerating expansion of human iPS cell-derived hepatic progenitor-like cells. Stem Cell Dev., 24, 1691-702, 2015 .

・ヒトiPS細胞由来肝前駆細胞の性状解析を、細胞表面に存在するタンパク質の網羅的発現解析から行った研究。ヒトiPS細胞由来肝前駆細胞の増殖に必要なシグナルとして、IGF受容体下流のシグナルなどを同定した。

 

(24) Ito K, Yamazaki S, Yamamoto R, Tajima Y, Yanagida A, Kobayashi T, Kato-Itoh M, Kakuta S, Iwakura Y, Nakauchi H, Kamiya A*, Gene Targeting Study Reveals Unexpected Expression of Brain expressed X-linked 2 in Endocrine and Tissue Stem/progenitor Cells in Mice. J Biol Chem. 2289, 29892-911, 2014

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(25) Ito K, Yanagida A, Okada K, Yamazaki Y, Nakauchi H, Kamiya A*. Mesenchymal progenitor cells in mouse fetal liver regulate differentiation and proliferation of hepatoblasts. Liver Int. 34, 1378-1390, 2014

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(26) Yanagida A, Ito K, Chikada H, Nakauchi H, Kamiya A*. An in vitro expansion system for generation of human iPS cell-derived hepatic progenitor-like cells exhibiting a bipotent differentiation potential. PLoS One, 8, e67541, 2013

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(27) Kiyohashi K, Kakinuma S, Kamiya A, Sakamoto N, Nitta S, Yamanaka H, Yoshino K, Fijuki J, Murakawa M, Kusano-Kitazume A, Shimizu H, Okamoto R, Azuma S, Nakagawa M, Asahina Y, Tanimizu N, Kikuchi A, Nakauchi H, Watanabe M. Wnt5a signaling mediates biliary differentiation of fetal hepatic stem/progenitor cells. Hepatology, 57, 2502-13, 2013

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(28) Oikawa T, Kamiya A*, Zeniya M, Chikada H, Hyuck AD, Yamazaki Y, Wauthier E, Tajiri H, Miller LD, Wang XW, Reid LM*, Nakauchi H*. Sal-like protein 4 (SALL4), a stem cell biomarker in liver cancers. Hepatology 57, 1469-83, 2013

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(29) Yamaguchi T, Hamanaka S, Kamiya A, Okabe M, Kawarai M, Wakiyama Y, Umino A, Hayama T, Sato H, Lee YS, Kato-Itoh M, Masaki H, Kobayashi T, Yamazaki S, Nakauchi H. Development of an All-in-One Inducible Lentiviral Vector for Gene Specific Analysis of Reprogramming. PLoS One. 7, e41007, 2012

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(30) Sekine K, Takebe T, Suzuki Y, Kamiya A, Nakauchi H, Taniguchi H. Highly efficient generation of definitive endoderm lineage from human induced pluripotent stem cells. Transplant Proc. 244, 1127-9, 2012

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(31) Okada K, Kamiya A*, Ito K, Yanagida A, Ito H, Kondou H, Nishina H, Nakauchi H*. Prospective Isolation and Characterization of Bipotent Progenitor Cells in Early Mouse Liver Development. Stem Cells Dev. 21, 1124-1133, 2012

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(32) Ito H, Kamiya A*, Ito K, Yanagida A, Okada K, Nakauchi H*. In vitro expansion and functional recovery of mature hepatocytes from mouse adult livers. Liver Int. 32, 592-601, 2012

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(33) Nishimura S, Manabe I, Nagasaki M, Kakuta S, Iwakura Y, Takayama N, Ooehara J, Otsu M, Kamiya A, Petrich B, Urano T, Kadono T, Sato S, Aiba A, Yamashita H, Sugiura S, Kadowaki T, Nakauchi H, Eto K, Nagai R. In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling. Blood. 119, e45-56, 2012

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(34) Onozuka I, Kakinuma S, Kamiya A, Miyoshi M, Sakamoto N, Kiyohashi K, Watanabe T, Funaoka Y, Ueyama M, Nakagawa M, Koshikawa N, Seiki M, Nakauchi H, Watanabe M. Cholestatic liver fibrosis and toxin-induced fibrosis are exacerbated in matrix metalloproteinase-2 deficient mice. Biochem Biophys Res Commun. 406, 134-40, 2011

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(35) Chiba T, Seki A, Aoki R, Ichikawa H, Negishi M, Miyagi S, Oguro H, Saraya A, Kamiya A, Nakauchi H, Yokosuka O, Iwama A. Bmi1 promotes hepatic stem cell expansion and tumorigenicity in both Ink4a/Arf-dependent and independent manners. Hepatology 52, 1111-1123, 2010

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(36) Kamiya A*, Kakinuma S, Yamazaki Y, Nakauchi H*. Enrichment and clonal culture of progenitor cells during mouse postnatal liver development in mice. Gastroenterology 137, 1114-1126, 2009.

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(37) Kakinuma S, Ohta H, Kamiya A, Yamazaki Y, Oikawa T, Okada K, Nakauchi H. Analyses of cell surface molecules on hepatic stem/progenitor cells in mouse fetal liver. J Hepatol. 51, 127-138, 2009.

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(38) Yamada A, Suzuki D, Miyazono A, Oshima K, Kamiya A, Zhao B, Takami M, Donnelly R, Itabe H, Yamamoto M, Kimura S, Kamijo R, IFN-γ down-regulates Secretoglobin 3A1 gene expression. Biochem. Biophys. Res. Com. 379, 964-968, 2009.

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(39) Oikawa T, Kamiya A*, Kakinuma S, Zeniya M, Nishinakamura R, Tajiri H, Nakauchi H*. Sall4 Regulates Cell Fate Decision in Fetal Hepatic Stem/Progenitor Cells. Gastroenterology 136, 1000-1011, 2009

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(40) Kamiya A*, Kakinuma S, Onodera M, Miyajima A, Nakauchi H*. Prospero-related homeobox 1 and liver receptor homolog 1 coordinately regulate long-term proliferation of murine fetal hepatoblasts. Hepatology 48, 252-64, 2008.

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(41) Eto K, Nishikii H, Ogaeri T, Suetsugu S, Kamiya A, Kobayashi T, Yamazaki D, Oda A, Takenawa T, Nakauchi H. The WAVE2/Abi1 complex differentially regulates megakaryocyte development and spreading: implications for platelet biogenesis and spreading machinery. Blood 110, 3637-47, 2007.

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(42) Suzuki A, Ivandini TA, Kamiya A, Nomura S, Yamanuki M, Matsumoto K, Fujishima A, Einaga Y, Direct electrochemical detection of sodium azide in physiological saline buffers using highly boron-doped diamond electrodes. Sensors and Actuators B 120, 500-507, 2007.

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(43) Barbier O, Girard H, Inoue Y, Duez H, Villeneuve L, Kamiya A, Fruchart JC, Guillemette C, Gonzalez FJ and Staels B. Hepatic expression of the UGT1A9 is governed by HNF4alpha. Mol. Pharm. 67, 241-249, 2005.

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(44) Kamiya A, Inoue Y, Kodama T and Gonzalez FJ. Hepatocyte nuclear factors 1alpha and 4alpha control expression of proline oxidase in adult liver. FEBS Lett. 578, 63-68, 2004.

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(45) Kamiya A and Gonzalez FJ. Tumor necrosis factor-a regulates mouse fetal hepatic maturation induced by oncostatin M and extracellular matrices. Hepatology 40, 527-536, 2004.

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(46) Kamiya A, Inoue Y and Gonzalez FJ. Role of the hepatocyte nuclear factor 4alpha in control of the pregnane X receptor during fetal liver development. Hepatology 37, 1375-1384, 2003.

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(47) Anzai H, Kamiya A, Shirato H, Takeuchi T and Miyajima A. Impaired differentiation of fetal hepatocytes in homozygous jumonji mice, Mech. Dev. 120, 791-800, 2003.

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(48) Matsui T, Kinoshita T, Morikawa Y, Tohya K, Katsuki M, Ito Y, Kamiya A and Miyajima A. K-Ras mediates cytokine-induced formation of E-cadherin-based adherens junctions during liver development. EMBO J. 21, 1021-1030, 2002.

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(49) Kamiya A, Kojima N, Kinoshita T, Sakai Y and Miyajima A. Maturation of fetal hepatocytes in vitro by extracellular matrices and oncostatin M: Induction of tryptophan oxygenase. Hepatology 35, 1351-1359, 2002.

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(50) Kamiya A, Kinoshita T and Miyajima A. Oncostatin M and hepatocyte growth factor induce hepatic maturation via distinct signaling pathways. FEBS Lett. 492, 90-94, 2001.

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(51) Ito Y, Matsui T, Kamiya A, Kinoshita T and Miyajima A. Retroviral gene transfer of signaling molecules into murine fetal hepatocytes defines distinct roles for the STAT3 and ras pathways during hepatic development. Hepatology 32, 1370-1376, 2000.

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(52) Kojima N, Kinoshita T, Kamiya A, Nakamura K, Nakashima K, Taga T and Miyajima A. Cell density-dependent regulation of hepatic development by a gp130-independent pathway. Biochem. Biophys. Res. Commun. 277, 152-158, 2000.

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(53) Kinoshita T, Sekiguchi T, Xu MJ, Ito Y, Kamiya A, Tsuji K, Nakahata T and Miyajima A. Hepatic differentiation induced by oncostatin M attenuates fetal liver hematopoiesis. Proc. Natl. Acad. Sci. USA. 96, 7265-7270, 1999.

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(54) Kamiya A, Kinoshita T, Ito Y, Matsui T, Morikawa Y, Senba E, Nakashima K, Taga T, Yoshida K, Kishimoto T and Miyajima A. Fetal liver development requires a paracrine action of oncostatin M through the gp130 signal transducer. EMBO J. 18, 2127-2136, 1999.

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(55) Kinoshita T, Shirouzu M, Kamiya A, Hashimoto K, Yokoyama S and Miyajima A. Raf/MAPK and rapamycin-sensitive pathways mediate the anti-apoptotic function of p21Ras in IL-3-dependent hematopoietic cells. Oncogene. 15, 619-627, 1997.

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(56) Ito Y, Yamasaki K, Iwahara J, Terada T, Kamiya A, Shirouzu M, Muto Y, Kawai G, Yokoyama S, Laue ED, Walchli M, Shibata T, Nishimura S and Miyazawa T. Regional polysterism in the GTP-bound form of the human c-Ha-Ras protein. Biochemistry 36, 9109-9119, 1997.

 

２．著書

(1) Kakinuma S, Kamiya A. A Rodent Model for Cell Transplantation of Hepatic Progenitor Cells. In Methods Mol Biol. “Hepatic Stem Cells” (edited by Tanimizu N.) 1905, 211-219, 2019. doi: 10.1007/978-1-4939-8961-4_19.

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(2) Kamiya A, Anzai K, Tsuruya K, Chikada H. Culture System of Bile Duct-Like Cystic Structures Derived from Human-Inducible Pluripotent Stem Cells. In Methods Mol Biol. “Hepatic Stem Cells” (edited by Tanimizu N.) 1905, 143-153, 2019. doi: 10.1007/978-1-4939-8961-4_13.

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(3) 紙谷聡英（分担執筆）：フローサイトメトリーQ&A （戸村道夫 編）, 2017年 11月

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(4) Kamiya A, Chikada H. Characteristics of hepatic progenitor cells during liver development and regeneration. In Stem Cells in Clinical Applications “Liver, Lung and Heart Regeneration” (edited by Phuc Van Pham), 2017, 3-13. doi: 10.1007/978-3-319-46693-4_1.

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(5)　紙谷聡英 「ヒトiPS細胞から肝細胞への分化誘導」 in “ｉＰＳ細胞の安全・高品質な作製技術”　(技術情報協会　編), 2016 10月

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(6) Yanagida A, Nakauchi H, Kamiya A. Generation and In Vitro Expansion of Hepatic Progenitor Cells from Human iPS Cells. In Methods Mol Biol. “iPS Cells: Generation Characterization and Differentiation –Methods and Protocols” (edited by Andras Nagy) 2015 .

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(7) 紙谷聡英、近田裕美　「肝臓の再生医療に向けた幹細胞研究の進展」　

In The Frontiers in Life Sciences “幹細胞研究と再生医療“　（中内博光　編）, 183-191, 2013.

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(8) Kamiya A, Nakauchi H.　Enrichment and clonal culture of hepatic stem/progenitor cells during mouse liver development. In Methods Mol Biol. “Epithelial Cell Culture Protocols.” (edited by Randell SH and Fulcher ML.) 2013;945:273-86. doi: 10.1007/978-1-62703-125-7_16

 

３．総説・解説

(1) Kamiya A.　Regulation of the survival and differentiation of hepatic stem/progenitor cells by cyclic retinoid.　Stem Cell Res Ther. 2015 May 29;6:109. doi: 10.1186/s13287-015-0099-9.

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(2) Kamiya A, and Chikada H, Human pluripotent stem cell-derived cholangiocytes: current status and future applications. Curr. Opin. Gastroenterol. 31, 233-8, 2015.

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(3) Kamiya A, Inagaki Y. Stem and progenitor cell systems in liver development and regeneration. Hepatol Res. 45, 29-37, 2015.

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(4) 及川恒一、紙谷聡英「幹細胞マーカーSALL4の肝癌治療法における可能性」 肝胆膵, 2014, 68, 437-444

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(5) 近田裕美、紙谷聡英 「肝細胞移植を用いた肝疾患の治療」細胞2013, 45, 314-317

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(6) 紙谷聡英 「ヒト多能性幹細胞からの肝幹・前駆細胞分化誘導系の構築」　消化器内科, 2013, 56, 316-323

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(7) 紙谷聡英 「発生過程・生体における肝幹・前駆細胞の分化誘導の分子メカニズム」　肝胆膵, 2012, 65, 29-35

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(8) Kamiya A, Miyajima A.　Mice with artificial human liver.　Hepatology. 55, 974-976, 2012.

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(9) Chiba T, Kamiya A, Yokosuka O, Iwama A. Cancer stem cell in hepatocellular carcinoma: Recent progress and perspective. Cancer Lett. 286, 145-153, 2009.

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(10) 紙谷聡英 「発生過程・成体における多能性幹細胞および肝幹細胞」　肝胆膵, 2008, 57, 347-353.

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(11) Kamiya A, Gonzalez FJ and Nakauchi H. Identification and differentiation of hepatic stem cells during liver development. Front Biosci. 11, 1302-1310, 2006.

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(12) 紙谷聡英、宮島篤 「初代培養系による肝臓の発生分化」　外科, 2001, 63, 563-570.

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(13) Miyajima A, Kinoshita T, Tanaka M, Kamiya A, Mukouyama Y, Hara T. Role of Oncostatin M in hematopoiesis and liver development. Cytokine Growth Factor Rev. 11, 177-183, 2000.

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(14) 紙谷聡英、宮島篤 「サイトカインによる細胞死の制御機構」　実験医学, 1998, 16, 495-500.

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(15) 紙谷聡英、宮島篤 「GM-CSF」 Surgery Frontier, 1996, 3(Suppl.), 145-150.

 

４．外部研究費

(1) 日本学術振興会 科学研究費助成事業 挑戦的研究（萌芽）

胆管オルガノイドと流体デバイスを用いたハイスループット創薬スクリーニング系の構築

研究期間 2021年度～2022年度

(2) 日本学術振興会 科学研究費助成事業 新学術領域研究（性スペクトラム）

肝臓の性差制御機構を利用した肝疾患治療法の開発

研究期間 2020年度～2021年度

(3) 日本学術振興会 科学研究費助成事業 基盤研究(B)

脂肪肝炎の発症・病態を制御する新規脂肪酸代謝システム

研究期間 2019年度～2021年度

(4) 日本学術振興会 科学研究費助成事業 挑戦的萌芽研究

マイクロ流体デバイスを用いたヒト多能性幹細胞由来胆管疾患解析系の構築

研究期間 2016年度～2017年度

(5) 日本学術振興会 科学研究費助成事業 基盤研究(B)

ゲノム改変型ヒト多能性幹細胞を用いた肝炎ウイルス感染・複製機構の解明

研究期間 2014年度～2017年度

(6) 日本学術振興会 科学研究費助成事業 挑戦的萌芽研究

ヒトiPS細胞由来肝幹細胞の自己複製を制御する内在性および外来性miRNAの解析

研究期間 2013年度～2014年度

(7) 日本学術振興会 科学研究費助成事業 新学術領域研究(研究領域提案型)

“上皮管腔組織の形成・維持と破綻における極性シグナル制御の分子基盤の確立”

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研究期間 2012年度～2013年度

(8) 日本学術振興会 科学研究費助成事業 若手研究(A)

ウイルス性慢性肝炎モデルのための免疫機能を保持したヒト肝細胞キメラマウスの作成

研究期間 2011年度～2013年度

(9) 厚生労働省 厚生労働省研究事業 厚生労働科学研究費補助金（肝炎等克服緊急対策研）

免疫機能を保持したヒト肝細胞キメラマウスによる慢性肝炎モデル作出

研究期間 2011年度～2013年度

(10) 日本学術振興会 科学研究費助成事業　若手研究(B)

肝発生初期における肝幹細胞の増殖・分化を制御する細胞間相互作用の解析

研究期間 2009年度～2010年度

(11) 日本学術振興会 科学研究費助成事業　若手研究(B)

肝幹細胞の増殖・分化制御の分子メカニズム

研究期間 2007年度～2008年度

(12) 日本学術振興会 科学研究費助成事業　若手研究(B)

肝臓の初期発生および成熟段階における液性因子・細胞外マトリクスの関与

研究期間 2005年度～2006年度